Proguanil Plus Sulfamethoxazole is not Causally Prophylactic in the Macaca mulatta—Plasmodium cynomolgi Model

Counterpoint: visceral adiposity is not causally related to insulin resistance.

Causally Related to Insulin Resistance I t has been known for over half a century that accumulation of fat in the upper body is associated with metabolic complications of obesity. The mechanism responsible for this association is widely believed to be insulin resistance, which is frequently present in individuals with upper-body obesity (1) and is associated with increased cardiovascular risk (...

Cystatin C Is Not Causally Related to Coronary Artery Disease

BACKGROUND Strong and independent associations between plasma concentration of cystatin C and risk of cardiovascular disease (CVD) suggests causal involvement of cystatin C. AIM The aim of our study was to assess whether there is a causal relationship between plasma concentration of cystatin C and risk of coronary artery disease (CAD) using a Mendelian Randomization approach. METHODS We est...

Correlates of severity of disease in Macaca mulatta infected with Plasmodium cynomolgi

Characterization of host responses associated with severe malaria through an integrative approach is necessary to understand the dynamics of a Plasmodium cynomolgi infection. In this study, we conducted temporal immune profiling, cytokine profiling and transcriptomic analysis of five Macaca mulatta infected with P. cynomolgi. This experiment resulted in two severe infections, and two mild infec...

Orangutans Not Infected with Plasmodium vivax or P. cynomolgi, Indonesia

After orangutans in Indonesia were reported as infected with Plasmodium cynomolgi and P. vivax, we conducted phylogenetic analyses of small subunit ribosomal RNA gene sequences of Plasmodium spp. We found that these orangutans are not hosts of P. cynomolgi and P. vivax. Analysis of >or=1 genes is needed to identify Plasmodium spp. infecting orangutans.

Paludrine (Proguanil) as a Suppressive and Prophylactic in P.-Vivax Infections